We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
MAE4, an eLtaS monoclonal antibody, blocks Staphylococcus aureus virulence.
- Authors
Liu, Yu; Feng, Jiannan; Lu, Qiang; Zhang, Xin; Gao, Yaping; Yan, Jun; Mu, Chunhua; Hei, Yan; Lv, Ming; Han, Gencheng; Chen, Guojiang; Jin, Peng; Hu, Weiguo; Shen, Beifen; Yang, Guang
- Abstract
Staphylococcus aureus causes a wide range of infectious diseases. Treatment of these infections has become increasingly difficult due to the widespread emergence of antibiotic-resistant strains; therefore, it is essential to explore effective alternatives to antibiotics. A secreted protein of S. aureus, known as eLtaS, is an extracellular protein released from the bacterial membrane protein, LtaS. However, the role of eLtaS in S. aureus pathogenesis remains largely unknown. Here we show eLtaS dramatically aggravates S. aureus infection by binding to C3b and then inhibiting the phagocytosis of C3b-deposited S. aureus. Furthermore, we developed a monoclonal antibody against eLtaS, MAE4, which neutralizes the activity of eLtaS and blocks staphylococcal evasion of phagocytosis. Consequently, MAE4 is capable of protecting mice from lethal S. aureus infection. Our findings reveal that targeting of eLtaS by MAE4 is a potential therapeutic strategy for the treatment of infectious diseases caused by S. aureus.
- Subjects
STAPHYLOCOCCUS; COMMUNICABLE disease treatment; PHYSIOLOGICAL effects of antibiotics; MEMBRANE proteins; IMMUNOGLOBULINS
- Publication
Scientific Reports, 2015, p17215
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep17215