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- Title
Enhanced renoprotective effect of HIF-1α modified human adipose-derived stem cells on cisplatin-induced acute kidney injury in vivo.
- Authors
Wang, Wei-Wei; Li, Ze-Zheng; Wang, Wei; Jiang, Yan; Cheng, Jin; Lu, Shi; Zhang, Jin-Yuan
- Abstract
Current therapeutic options for acute kidney injury (AKI) are limited to the use of supportive measures and dialysis. A recent approach that has sparked great interest and gained enormous popularity is the implantation of stem cells to repair acutely damaged kidney organ. Hypoxia inducible factor-1α (HIF-1α) is effective in protecting the kidney from ischemia and nephrotoxicity. In this study, we investigated whether HIF-1α-modified adipose-derived stem cells (ASCs) had an enhanced protective effect on cisplatin-induced kidney injury in vivo. Cisplatin-induced AKI was established in nude mice. Our study demonstrated that HIF-1α-modified ASCs obviously promoted the recovery of renal function, ameliorated the extent of histologic injury and reduced renal apoptosis and inflammation, but HIF-1α-modified ASCs homed to kidney tissues at very low levels after transplantation. In addition, we also found that HIF-1α-modified ASCs significantly increased HO-1 expression in cisplatin-induced AKI in vivo. Thus, our study indicated HIF-1α-modified ASCs implantation could provide advanced benefits in the protection again AKI, which will contribute to developing a new therapeutic strategy for the treatment of AKI.
- Subjects
HUMAN stem cells; CISPLATIN; KIDNEY injuries; ADIPOSE tissues; ISCHEMIA; KIDNEY transplantation; THERAPEUTICS
- Publication
Scientific Reports, 2015, p10851
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep10851