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- Title
Expression of IL-33 in chronic lesionai skin of canine atopic dermatitis.
- Authors
Asahina, Ryota; Nishida, Hidetaka; Kamishina, Hiroaki; Maeda, Sadatoshi
- Abstract
Background - In humans, interleukin (IL)-33 plays a criticalrole in the enhancement of allergic skin inflammation. However, it currently remains unclear whether IL-33 is involved in the pathogenesis of canine atopic dermatitis (cAD). Objectives - To examine the expression of IL-33 in chronic lesionai skin of cAD. Animals - Eight dogs with spontaneous cAD and five healthy dogs were used. Methods - The transcription of il-33 in chronic lesionai skin of cAD was quantified by quantitative reverse transcription PCR. The expression of IL-33 was evaluated immunohistochemically using an anti-human IL-33 monoclonal antibody w i t h cross-reactivity to canine IL-33. Results - The transcription levels of il-33 in chronic lesionai skin of cAD were significantly higher than those in normal skin of healthy dogs. Keratinocytes were a major cellular source of IL-33 production in chronic lesional skin of cAD. Conclusions and clinical importance - The results indicate that IL-33 is involved in chronic lesional skin of cAD.
- Subjects
KERATINOCYTES; ATOPIC dermatitis; INTERLEUKINS; INTERLEUKIN-33; SKIN diseases
- Publication
Veterinary Dermatology, 2018, Vol 29, Issue 3, p246
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/vde.12531