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- Title
Cell-free DNA analysis after reduction in multifetal pregnancy.
- Authors
Bevilacqua, E.; Chen, K.; Wang, Y.; Doshi, J.; White, K.; Marchin, J.; Conotte, S.; Jani, J. C.; Schmid, M.; de Marchin, J
- Abstract
Fetal demise in a multifetal pregnancy can complicate aneuploidy screening as the cell-free DNA (cfDNA) from the non-viable conception may lead to a non-invasive prenatal testing result that is discordant with that of the viable fetus[1], [2]. GLO:F0Y/01jan20:uog20366-fig-0001.jpg PHOTO (COLOR): (a) Chromosome-21 aneuploidy values () and Y-chromosome values () in twin pregnancy before fetal reduction at 19 weeks () and post-reduction () at 22, 27 and 32 weeks. Chromosome-21 aneuploidy value represents relative signal from chromosome 21 compared with that expected in disomy; value of 0 represents disomy 21 and that of 1 represents trisomy 21.
- Subjects
MULTIPLE pregnancy; DNA analysis; PREGNANCY; PRENATAL genetic testing
- Publication
Ultrasound in Obstetrics & Gynecology, 2020, Vol 55, Issue 1, p132
- ISSN
0960-7692
- Publication type
letter
- DOI
10.1002/uog.20366