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- Title
Prediabetes and diabetes are both risk factors for adverse outcomes in infective endocarditis.
- Authors
Wei, X.‐B.; Liu, Y.‐H.; Huang, J.‐L.; Chen, X.‐L.; Yu, D.‐Q.; Tan, N.; Chen, J.‐Y.; He, P.‐C.
- Abstract
Aim: Diabetes is a risk factor in infective endocarditis. However, few studies have focused on the prognostic value of prediabetes in infective endocarditis. This analysis aimed to explore the relationship between prediabetes and outcomes for people with infective endocarditis. Methods: Diabetes and prediabetes definitions were based on the American Diabetes Association 2014 criteria. A total of 866 people who had been consecutively diagnosed with infective endocarditis between January 2009 and July 2015 were included in the analysis. They were divided into three groups: normoglycaemia (n = 469), prediabetes (n = 246) and diabetes (n = 151). Univariate and multivariate analyses were used to identify risk factors for adverse outcomes. Results: Overall in‐hospital mortality was 8.5% (74 of 866), and differed significantly among the normoglycaemia, prediabetes and diabetes groups (3.4%, 12.6% and 17.9%, respectively; P < 0.001). Compared with the normoglycaemia group, the adjusted odds ratio for in‐hospital death was 2.42 [95% confidence interval (CI) 1.11–5.31; P = 0.027) for prediabetes and 3.39 (95% CI 1.48–7.80; P = 0.004) for diabetes. The cumulative long‐term death rate was significantly higher in the prediabetes or diabetes groups than in the normoglycaemia group (log‐rank = 34.82; P < 0.001). Conclusion: In addition to diabetes, prediabetes was also associated with a higher risk of in‐hospital and long‐term mortality among people with infective endocarditis. Therefore, attention should be paid to this population. What's new: Compared with normoglycaemic people, those with infective endocarditis and diabetes demonstrated higher in‐hospital and long‐term mortality.Prediabetes was also a significant risk factor for mortality in people with infective endocarditis.Early identification and better monitoring and treatment is also suggested for people with prediabetes in order to improve their prognoses.
- Subjects
DIABETES complications; DIAGNOSIS of endocarditis; ENDOCARDITIS; AMERICAN Diabetes Association; CONFIDENCE intervals; MULTIVARIATE analysis; PREDIABETIC state; STATISTICS; HOSPITAL mortality; LOG-rank test; ODDS ratio; DISEASE complications; DISEASE risk factors
- Publication
Diabetic Medicine, 2018, Vol 35, Issue 11, p1499
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/dme.13761