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- Title
Nutrient vitamins enabled metabolic regulation of ferroptosis via reactive oxygen species biology.
- Authors
Junjie Wu; Yanting Shi; Man Zhou; Min Chen; Shuying Ji; Xingxing Liu; Mengjiao Zhou; Rui Xia; Xiaohua Zheng; Weiqi Wang
- Abstract
Vitamins are dietary components necessary for cellular metabolic balance, especially redox homeostasis; deficient or excessive supply may give rise to symptoms of psychiatric disorders. Exploring the nutritional and metabolic pathways of vitamins could contribute to uncovering the underlying pathogenesis of ferroptosis-associated diseases. This mini-review aims to provide insights into vitamins closely linked to the regulation of ferroptosis from the perspective of cellular reactive oxygen species biology. The mainstream reprogramming mechanisms of ferroptosis are overviewed, focusing on unique biological processes of iron metabolism, lipid metabolism, and amino acid metabolism. Moreover, recent breakthroughs in therapeutic interventions targeting ferroptosis via fully utilizing vitamin-based pharmacological tools were overviewed, covering vitamins (B, C, E, and K). Finally, mechanism insight related to vitamin-associated nutrient signaling was provided, highlighting the pharmacological benefits of metabolically reprogramming ferroptosis-associated diseases.
- Subjects
AMINO acid metabolism; REACTIVE oxygen species; METABOLIC regulation; IRON metabolism; LIPID metabolism
- Publication
Frontiers in Pharmacology, 2024, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2024.1434088