We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The HNF-1α-SNARE connection.
- Authors
Yamagata, K.; Nammo, T.; Sato, Y.; Saisho, K.; Shoda, H.; Fukui, K.
- Abstract
Maturity-onset diabetes of the young (MODY) is a monogenic form of type 2 diabetes mellitus that is characterized by impairment of glucose-stimulated insulin secretion from pancreatic β-cells. We previously reported that heterozygous mutations of the hepatocyte nuclear factor (HNF)-1α gene cause a form of MODY (MODY3). We have subsequently found that collectrin, a recently cloned kidney-specific gene of unknown function, is a novel target of HNF-1α in pancreatic β-cells. In addition, we have demonstrated that collectrin forms a complex with the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex by direct interaction with snapin, a protein that is thought to be involved in neurotransmission by binding to synaptosomal-associated protein, 25 KD (SNAP25). Collectrin favours the formation of SNARE complexes and controls insulin exocytosis.
- Subjects
DIABETES; EXOCYTOSIS; GLUCOSE; INSULIN; LIVER cells; NEURAL transmission
- Publication
Diabetes, Obesity & Metabolism, 2007, Vol 9, p40
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/j.1463-1326.2007.00773.x