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- Title
Pharmacokinetics of florfenicol in veal calves.
- Authors
VARMA, K.J.; ADAMS, P. E.; POWERS, T. E.; POWERS, J. D.; LAMENDOLA, J. F.
- Abstract
Varma, K.J., Adams, P.E., Powers, T.E., Powers, J.D. & Lamendola, J.F. Pharmacokinetics of florfenicol in veal calves. J. vet. Pharmacol. Therap. 9, 412-425. The pharmacokinetic disposition of florfenicol was described in veal calves after administration of a single 22-mg/kg dose intravenously, orally after a 12-h fast and orally 5 min post feeding. Both serum concentrations and urinary excretion were studied. After intravenous administration the median elimination half-life was 171.9 min while the half-life of the distribution phase was 5.9 min. The median body clearance ( Cl) and apparent volume of distribution ( Vz) were 2.85 ml/kg/min and 0.78 1/kg, respectively. Following oral administration the median bio-availability ( f) was 0.88 for calves dosed after a 12-h fast and 0.65 for calves dosed 5 min post feeding. Calves given the oral doses had a complex absorption pattern with delayed absorption. Slightly more than 50% of the administered dose both orally and intravenously was recovered as unchanged florfenicol in the urine by 30 h.
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 1986, Vol 9, Issue 4, p412
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/j.1365-2885.1986.tb00062.x