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- Title
The sequential organ failure assessment ( SOFA) score is prognostically superior to the model for end-stage liver disease ( MELD) and MELD variants following paracetamol (acetaminophen) overdose.
- Authors
Craig, D. G. N.; Reid, T. W. D. J.; Wright, E. C.; Martin, K. G.; Davidson, J. S.; Hayes, P. C.; Simpson, K. J.
- Abstract
Summary Background The prognostic value of the model for end-stage liver disease ( MELD) and sodium-based MELD variants in predicting survival following paracetamol overdose remains unclear. Aim To examine the prognostic accuracy of sodium-based MELD variants in paracetamol-induced acute liver injury compared with the sequential organ failure assessment ( SOFA) score. Methods Retrospective analysis of 138 single time point paracetamol overdoses admitted to a tertiary liver centre. Individual laboratory samples were correlated with the corresponding clinical parameters in relation to time post-overdose, and the daily MELD, MELD- Na, MELDNa, MESO, iMELD, UKELD, updated MELD and SOFA scores were calculated. Results Sixty-six (47.8%) patients developed hepatic encephalopathy, of whom 7 were transplanted and 21 died without liver transplantation. SOFA had a significantly greater area under the receiver operator characteristic for the prediction of spontaneous survival compared with MELD at both 72 ( P = 0.024) and 96 ( P = 0.017) h post-overdose. None of the sodium-based MELD variants improved the prognostic accuracy of MELD. A SOFA score >6 by 72 h or >7 by 96 h, post-overdose predicted death/transplantation with a negative predictive value of 96.9 (95% CI 90.2-99.4) and 98.8 (95% CI 93.6-99.9) respectively. SOFA and MELD had similar accuracy for predicting the development of hepatic encephalopathy ( P = 0.493). Conclusions The SOFA score is superior to MELD in predicting spontaneous survival following paracetamol-induced acute liver injury. Modification of the MELD score to include serum sodium does not improve prognostic accuracy in this setting. SOFA may have potential as a quantitative triage marker following paracetamol overdose.
- Subjects
LIVER failure; LIVER transplantation; ACETAMINOPHEN; DRUG overdose; HEPATIC encephalopathy; QUANTITATIVE research
- Publication
Alimentary Pharmacology & Therapeutics, 2012, Vol 35, Issue 6, p705
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2012.04996.x