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- Title
Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?
- Authors
Allsopp, Richard C.; Weissman, Irving L.
- Abstract
Discusses the role of telomerase in hematopoietic system. Telomere shortening and senescence in the absence of telomerase; Telomere shortening and senescence in the presence of telomerase; Effect of over-expression of telomerase reverse transcriptase on the replicative capacity of hematopoietic stem cells during transplantation.
- Subjects
TELOMERASE; HEMATOPOIETIC system; TELOMERES
- Publication
Oncogene, 2002, Vol 21, Issue 21, p3270
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1205314