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- Title
A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?
- Authors
Huiskamp, Marijn; Moumdjian, Lousin; van Asch, Paul; Popescu, Veronica; Schoonheim, Menno Michiel; Steenwijk, Martijn D; Vanzeir, Ellen; van Wijmeersch, Bart; Geurts, Jeroen JG; Feys, Peter; Hulst, Hanneke E
- Abstract
Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.
- Subjects
MNEMONICS; RUNNING training; FUNCTIONAL magnetic resonance imaging; FUNCTIONAL connectivity; HIPPOCAMPUS (Brain)
- Publication
Multiple Sclerosis Journal, 2020, Vol 26, Issue 12, p1594
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458519863644