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- Title
S.9.1 Lung ultrasound for the screening of interstitial lung disease in SSc.
- Authors
Barskova, T.; Gargani, L.; Conforti, M. L.; Guiducci, S.; Bruni, C.; Moggi Pignone, A.; Picano, E.; Matucci Cerinic, M.
- Abstract
Background. A high percentage of SSc patients develop interstitial lung disease (ILD) during the course of the disease. Promising data have recently shown that lung US (LUS) is able to detect ILD by the evaluation of B-lines (previously called US lung comets), the sonographic marker of pulmonary interstitial syndrome.Objective. To evaluate whether LUS could be employed for an early screening of ILD in patients with a very early diagnosis of SSc.Methods. Sixty-eight consecutive SSc patients [65 females, mean age 51 (13) years] who underwent a clinically driven chest high-resolution CT (HRCT) were evaluated by LUS for detection of B-lines. Among them, 24 patients fulfilled the criteria for a Very Early Diagnosis of SSc (VEDOSS).Results. ILD was present at HRCT in 69% of the total population and in 65% of the VEDOSS population. A significant positive linear correlation was found between B-line numbers and the presence of ILD at HRCT (r = 0.55; P < 0.001) in all patients. When considering only the VEDOSS population, the concordance rate between the two examinations was 88%, with a sensitivity of 96%, a negative predictive value of 88%, specificity of 50% and positive predictive value of 78%.Conclusions. ILD appears very early in SSc patients. Presence of B-lines at LUS examination correlates with ILD at HRCT. LUS is very sensitive to detect early ILD even in patients with very early diagnosis of SSc. The use of LUS as a screening tool for ILD seems feasible to guide further investigation with HRCT.
- Subjects
ARTHRITIS diagnosis; INTERSTITIAL lung diseases; SYNOVITIS; SYSTEMIC scleroderma; CONFERENCES &; conventions; MEDICAL screening; ULTRASONIC imaging; PROGNOSIS; DIAGNOSIS
- Publication
Rheumatology, 2012, Vol 51, Issue suppl_2, pii17
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/ker509