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- Title
Bone Marrow Stromal Cells Improve the Formalin Tonic Pain and Feeding Behavior in the Complete Thoracic Spinal Cord Injury in Rats.
- Authors
Kumar, Suneel; Jain, Suman; Mohanty, Sujata; Velpandian, Thirumurthy; Mathur, Rashmi
- Abstract
Bone marrow stromal cells (BMSC) have been investigated in the central nervous system repair after injury. However, the effectiveness of these cells in the treatment of spinal cord injury (SCI) induced hyperalgesia, allodynia, and hypoalgesia is far from clear. In this study, we investigated the therapeutic effect of BMSC on formalin tonic pain and feeding behavior after thoracic complete SCI. Adult male rats underwent complete transection of the spinal cord and later at day 9 of SCI received a direct injection of pre-labeled BMSC cells around the injury site. Formalin pain behavior was studied once at the end of week 8 after SCI while feeding behavior was studied every day preand post-SCI. After the formalin pain study, rats were sacrificed for histological and neurochemical studies. Formalin pain behavior was decreased after SCI at week 8. This formalin pain behavior partially recovered in the BMSC transplanted rats. During the study period, feeding behavior was affected severely after SCI. However, it was improved in the BMSC group of rats. Neurochemicals such as serotonin and dopamine were affected after SCI in different brain regions which were restored partially by BMSC transplantation. Histological studies revealed the presence of pre-labeled BMSC that filled the lesion cavities in the transplanted group. Data suggest the beneficial effect of BMSC transplantation on supraspinal mediated feeding and formalin tonic pain behaviors that are associated with altered neurotransmitter levels in the SCI rats.
- Subjects
MESENCHYMAL stem cells; SPINAL cord injuries; HYPERALGESIA; ANIMAL feeding behavior; SEROTONIN
- Publication
Journal of Stem Cells, 2018, Vol 13, Issue 4, p157
- ISSN
1556-8539
- Publication type
Article