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- Title
ERp29 forms a feedback regulation loop with microRNA-135a-5p and promotes progression of colorectal cancer.
- Authors
Huang, Jiebin; Jing, Mengxia; Chen, Xixi; Gao, Yuanqi; Hua, Huiying; Pan, Chun; Wu, Jing; Wang, Xinqiong; Chen, Xuehua; Gao, Yujing; Xu, Chundi; Li, Pu
- Abstract
Expression of endoplasmic reticulum (ER) stress-associated genes is often dysregulated in cancer progression. ER protein 29 (ERp29) is abnormally expressed in many neoplasms and plays an important role in tumorigenesis. Here, we showed ERp29 is a novel target for microRNA-135a-5p (miR-135a-5p) to inhibit the progression of colorectal cancer (CRC); correspondingly, ERp29 acts as an oncoprotein in CRC by promoting proliferation and metastasis of CRC cells, and suppressing apoptosis of the cells. More importantly, we found that miR-135a-5p expression is reversely upregulated by ERp29 through suppressing IL-1β-elicited methylation of miR-135a-5p promoter region, a process for enterocyte to maintain a balance between miR-135a-5p and ERp29 but dysregulated in CRC. Our study reveals a novel feedback regulation loop between miR-135a-5p and ERp29 that is critical for maintaining appropriate level of each of them, but partially imbalanced in CRC, resulting in abnormal expression of miR-135a-5p and ERp29, which further accelerates CRC progression. We provide supporting evidence for ERp29 and miR-135a-5p as potential biomarkers for diagnosis and treatment of CRC.
- Publication
Cell Death & Disease, 2021, Vol 12, Issue 11, p1
- ISSN
2041-4889
- Publication type
Article
- DOI
10.1038/s41419-021-04252-z