We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association.
- Authors
Bogdan, Maria; Meca, Andreea Daniela; Boldeanu, Mihail Virgil; Gheorghe, Dorin Nicolae; Turcu-Stiolica, Adina; Subtirelu, Mihaela-Simona; Boldeanu, Lidia; Blaj, Mihaela; Botnariu, Gina Eosefina; Vlad, Cristiana Elena; Foia, Liliana Georgeta; Surlin, Petra
- Abstract
Ascorbic acid (vitamin C) is an important water-soluble vitamin found in many fruits and vegetables. It has well-documented beneficial effects on the human body and is used as a supplement, alone or in combination with other vitamins and minerals. Over recent years, research has focused on possible new therapeutic actions in chronic conditions including periodontal disease (PD). We conducted a systematic review on clinical trials from four databases (PubMed, Clinical Trials, Cochrane, Web of Science) which measured plasmatic/salivary levels of ascorbic acid in PD–diabetes mellitus (DM) association. Six studies were included in our review, three of them analyzing patients with different grades of PD and DM who received vitamin C as a treatment (500 mg vitamin C/day for 2 months and 450 mg/day for 2 weeks) or as part of their alimentation (guava fruits), in combination with standard therapies and procedures. Decreased levels of vitamin C were observed in PD patients with DM but data about efficacy of vitamin C administration are inconclusive. Given the important bidirectional relationship between PD and DM, there is a strong need for more research to assess the positive effects of ascorbic acid supplementation in individuals suffering from both diseases and also its proper regimen for these patients.
- Subjects
THERAPEUTIC use of vitamin C; SALIVA analysis; DIABETES; DIETARY supplements; INFORMATION storage &; retrieval systems; MEDICAL databases; MEDLINE; ONLINE information services; PERIODONTAL disease; VITAMIN C; SYSTEMATIC reviews; COMORBIDITY; TREATMENT effectiveness
- Publication
Nutrients, 2020, Vol 12, Issue 2, p553
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12020553