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- Title
Ethanolic Extracts of Artemisia apiacea Hance Improved Atopic Dermatitis-Like Skin Lesions In Vivo and Suppressed TNF-Alpha/IFN-Gamma–Induced Proinflammatory Chemokine Production In Vitro.
- Authors
Yang, Ju-Hye; Lee, Esther; Lee, BoHyoung; Cho, Won-Kyung; Ma, Jin Yeul; Park, Kwang-Il
- Abstract
<italic>Artemisia apiacea</italic> Hance is a traditional herbal medicine used for treating eczema and jaundice in Eastern Asia including China, Korea, and Japan. However, the biological and pharmacological actions of <italic>Artemisia apiacea</italic> Hance in atopic dermatitis (AD) are not fully understood. An ethanolic extract of <italic>Artemisia apiacea</italic> Hance (EAH) was tested in vitro and in vivo to investigate its anti-inflammatory activity and anti-atopic dermatitis effects. The results showed that EAH dose-dependence inhibited production of regulated on activation, normal T-cell expressed and secreted (RANTES), interleukin (IL)-6, IL-8, and thymus and activation-regulated chemokine (TARC). EAH inhibited the activation of p38, extracellular signal-regulated kinases (ERK), and STAT-1 and suppressed the degradation of inhibited both nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha (IκB-α) in TNF-α/IFN-γ–stimulated HaCaT cells. EAH also suppressed the translocation of inflammation transcription factors such as NF-κB p65 in TNF-α/IFN-γ–stimulated HaCaT cells. In addition, EAH reduced 2,4-dinitrochlorobenzene (DNCB)-induced ear thickness and dorsal skin thickness in a dose-dependent manner. EAH appeared to regulate chemokine formation by inhibiting activation of and ERK as well as the NK-κB pathways. Furthermore, EAH significantly improved the skin p38 conditions in a DNCB-induced AD-like mouse model.
- Subjects
ATOPIC dermatitis; CARRIER proteins; CELLULAR signal transduction; CHEMOKINES; EAR; EAR diseases; ETHANOL; HERBAL medicine; INTERFERONS; INTERLEUKINS; CHINESE medicine; PROTEIN kinases; SKIN; SKIN abnormalities; TUMOR necrosis factors; WORMWOOD; DNA-binding proteins; BENZENE derivatives; IN vitro studies; IN vivo studies; PREVENTION
- Publication
Nutrients, 2018, Vol 10, Issue 7, p806
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10070806