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- Title
Androgen Suppression and Radiation vs Radiation Alone for Prostate Cancer.
- Authors
D'Amico, Anthony V.; Ming-Hui Chen; Renshaw, Andrew A.; Loffredo, Marian; Kantoff, Philip W.
- Abstract
This article reports on a clinical trial to test the effects of androgen suppression with radiation to radiation alone for the treatment of prostate cancer. Studies have shown better survival when androgen suppression therapy (AST) is combined with external bean radiation therapy (RT) and the treatment has become the standard of care. However, several cohort studies suggest that AST can cause an increased risk of cardiovascular events in older men. It is possible that comorbidities may increase the negative effects of the treatment. The study found that the combination treatment did increase overall survival in the patients but was unable to assess if comorbidities interacted with the treatment.
- Subjects
CLINICAL trial registries; PROSTATE cancer treatment; ANTIANDROGENS; ANDROGENS; RADIOTHERAPY; CARDIOVASCULAR diseases; HEART disease risk factors; COMORBIDITY; DRUG side effects; HEALTH outcome assessment
- Publication
JAMA: Journal of the American Medical Association, 2008, Vol 299, Issue 3, p289
- ISSN
0098-7484
- Publication type
Article