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- Title
The contribution of BDNF and 5-HTT polymorphisms and early life stress to the heterogeneity of major depressive disorder: A preliminary study.
- Authors
Quinn, Candice R; Dobson-Stone, Carol; Outhred, Tim; Harris, Anthony; Kemp, Andrew H
- Abstract
Objective: Two reported genetic polymorphisms related to the production of brain-derived neurotrophic factor (BNDF) and reuptake by the serotonin transporter (5-HTT) appear to contribute to depression in combination with stressful life events. The aim of the current study was to investigate the contribution of early life stress (ELS), BDNF (Val versus Met alleles) and 5-HTT polymorphisms (L versus S alleles) to melancholic (n = 65) and non-melancholic depression (n = 59).Methods: A mediation approach ((G × G) × E mediation model) was employed to confirm the indirect effects of ELS on the relationship between 5-HTTPLR × BDNF polymorphism combinations and depression subtype. A series of binary logistic regressions were then conducted to determine whether genotype, ELS, and their interaction were able to predict depression subtype.Results: Key findings indicated that BDNF and 5-HTT polymorphisms in combination with ELS contributed to the development of non-melancholic depression. An interaction between BDNF and ELS increased the risk of non-melancholia by 3.327, whereas the interaction between 5-HTT and ELS increased risk by 2.406.Conclusion: The results support a role for genetic factors in the development of non-melancholia. The lack of findings in melancholia indicates that other mechanisms may underlie the subtype. Alternatively, null findings may reflect a Type II error associated with a small sample size. Future studies should consider further examination of differential gene–environment interactions for melancholia versus non-melancholia.
- Subjects
DIAGNOSIS of mental depression; MENTAL depression genetics; ALLELES; CHI-squared test; MENTAL depression; GENES; GENETIC polymorphisms; HAMILTON Depression Inventory; LIFE change events; MEMBRANE proteins; NERVE tissue proteins; POLYMERASE chain reaction; QUESTIONNAIRES; RESEARCH; RESEARCH funding; LOGISTIC regression analysis; PSYCHOLOGICAL stress; EVALUATION research; CONTROL groups; DATA analysis software; DESCRIPTIVE statistics; NUCLEIC acid amplification techniques; GENETICS
- Publication
Australian & New Zealand Journal of Psychiatry, 2012, Vol 46, Issue 1, p55
- ISSN
0004-8674
- Publication type
Article
- DOI
10.1177/0004867411430878