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- Title
EXPRESSION LEVELS OF MIR-423-5P AND MIR-664B-5P IN PATIENTS WITH FAMILIAL AND SPORADIC OVARIAN CARCINOMA.
- Authors
Kurt, Busra; Avsar, Mukaddes; Tuncer, Seref Bugra; Ghafour, Arash Adamnejad; Kuru, Gozde; Kılıç, Seda; Erdogan, Ozge Sukruoglu; Akdeniz, Demet; Celik, Betul; Saip, Pınar; Yazici, Hulya
- Abstract
OBJECTIVES: miRNAs play an important role in the early diagnosis of ovarian cancer, prognosis and chemotherapy sensitivity. Our study was aimed to validate and investigate the expression of miR-423-5p and miR-664b-5p, among the miRNAs found to be important for ovarian cancer etiology in our previous study in the large cohorts of the peripheral blood of familial and sporadic ovarian cancer patients (150 cases) and healthy individuals 100 cases) MATERIAL&METHODS: Expression analysis was performed using the Real- Time PCR and the results were statistically evaluated with the SPSS v21.0. RESULTS: When the expression results of ovarian cancer patients were evaluated, it was found that the expression of miR-423-5p increased by 2.35 times and miR-664b-5p expression increased 2.47 times in ovarian cancer patients compared to the healthy control group. In the subgroup of ovarian cancer patients in comparison with the control group, the miR-423-5p expression level was higher in patients both ovarian and breast cancer diagnosis although the level of miR- 423-5p was found as decreased in the patients with diagnosed both ovarian and endometrial carcinoma. In the subgroup of ovarian cancer patients in comparison with the control group, the miR-664b-5p expression level was 1.95 fold higher in patients both ovarian and breast cancer diagnosis although the level of miR-664b- 5p was found 0.27 fold decreased in the patients with diagnosed both ovarian and endometrial carcinoma. CONCLUSIONS: The increased expression level of both miR-423-5p and miR- 664b-5p suggests that they may be a possible biomarker for ovarian carcinoma. The decreased miR-664b-5p expression might be a biomarker for BRCA associated cancers.
- Subjects
CANCER diagnosis; ETIOLOGY of cancer; OVARIAN cancer; CARCINOMA
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2019, Vol 44, p60
- ISSN
0250-4685
- Publication type
Article