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- Title
Nickel-Catalyzed Kumada Coupling of Benzyl Chlorides and Vinylogous Derivatives.
- Authors
Soler‐Yanes, Rita; Guisán‐Ceinos, Manuel; Buñuel, Elena; Cárdenas, Diego J.
- Abstract
Conditions for the fast Ni-catalyzed Kumada-type cross-coupling of functionalized benzyl and allyl chlorides with alkylmagnesium reagents were discovered. The use of Ni(acac)2-TMEDA (acac = acetylacetonate, TMEDA = N, N, N′, N′-tetramethyl-1,2-ethylenediamine) allows the presence of reactive functional groups on the electrophile. On the other hand, the use of diallyl ether was shown to provide fast coupling at low temperature with a low catalyst loading. The reaction seems to follow a radical pathway.
- Subjects
CHLORINE compounds; CATALYSIS research; ELECTROPHILES; ETHERS; CATALYSTS
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 30, p6625
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201403007