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- Title
Two-Step Synthesis of 2-Aminoindolizines from 2-Alkylpyridines.
- Authors
Kucukdisli, Murat; Opatz, Till
- Abstract
An efficient method for the synthesis of 2-aminoindolizines by the 5- exo- dig cyclization of 2-alkyl-1-(1-cyanoalkyl)pyridinium salts has been developed. These substrates were prepared by N-alkylation of 2-alkylpyridines with readily available cyanohydrin triflates. The method allows the introduction of various substituents at the 1-, 3-, 6-, 7-, and 8-positions and leaves no undesired acceptor groups in the products.
- Subjects
HETEROCYCLIC compounds; ANNULATION; ALKYLATION; RING formation (Chemistry); YLIDES
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 26, p5836
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402618