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- Title
AKUTNO ODBACIVANJE TRANSPLANTIRANOG BUBREGA.
- Authors
HALILČEVIĆ, ALMA; HODŽIĆ, EMIR; MEŠIĆ, ENISA; TRNAČEVIĆ, SENAID; IVELJIĆ, IVANA
- Abstract
Diagnosis of acute kidney allograft rejection is based on the biochemical findings and ultrasound examination of the kidneys. Aim of the case report is to present complexity and importance of timely and targeting treatment of acute antibody-mediated allograft rejection. A 32 year old man presented with terminal renal failure. Hospitalisation was because completing the clinical treatment for renal transplantation. Patient basic disease is Alport syndrome and was reason of the chronic dialysis since six years. Seventh posttransplant day there was anuria, hypervolemia, hypertension, with acute renal failure. Underwent renal biopsy. The biochemical findings were fall in blood counts, thrombocytopenia, undetectable haptoglobin, acute renal failure and biopsy findings of acute humoral rejection confirmed the clinical picture associated hemolytic uremic syndrome. Acute antibody-mediated rejection of kidney is based on the recognition of the characteristic histological markers and C4d detection of donor-specific antibodies. Hemolytic-uremic syndrome can occur in 15% of patients during treatment calcineurin inhibitors after transplantation and is characterized by: acute renal failure, hypertension, microangiopathic hemolytic anemia, thrombocytopenia and hyperbilirubinemia. Acute rejection is one of the most important factors influencing long-term graft survival. The number, type and time of occurrence of acute rejection were the main predictors of long-term graft survival.
- Publication
Acta Medica Croatica, 2014, Vol 68, p176
- ISSN
1330-0164
- Publication type
Case Study