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- Title
Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients.
- Authors
Koning, Rutger; Bastard, Paul; Casanova, Jean-Laurent; Brouwer, Matthijs C.; van de Beek, Diederik; with the Amsterdam U.M.C. COVID-19 Biobank Investigators; van Agtmael, Michiel; Algera, Anne Geke; Appelman, Brent; van Baarle, Frank; Bax, Diane; Beudel, Martijn; Bogaard, Harm Jan; Bomers, Marije; Bonta, Peter; Bos, Lieuwe; Botta, Michela; de Brabander, Justin; Bree, Godelieve; de Bruin, Sanne
- Abstract
Disease course was complicated by thromboembolic events in 3 of 6 patients (50%), acute kidney injury in 4 of 6 patients (67%) and superinfections in 4 of 6 patients (67%). Here we describe clinical characteristics of COVID-19 patients with auto-Abs neutralizing IFN-I, a subset of patients described by Bastard et al. [[1]].
- Subjects
COVID-19; TYPE I interferons; AUTOANTIBODIES; ACUTE kidney failure
- Publication
Intensive Care Medicine, 2021, Vol 47, Issue 6, p704
- ISSN
0342-4642
- Publication type
letter
- DOI
10.1007/s00134-021-06392-4