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- Title
Elevation of creatine kinase in acute severe asthma is not of cardiac origin.
- Authors
Lovis, Christian; Mach, François; Unger, Pierre-François; Bouillie, Muriel; Chevrolet, Jean-Claude; Lovis, C; Mach, F; Unger, P F; Bouillie, M; Chevrolet, J C
- Abstract
<bold>Objective: </bold>To study prospectively if, when plasma creatine kinase (CK) and plasma myoglobin are elevated, the origin of these abnormalities is cardiac or not, by measuring cardio-specific troponin T (cTT).<bold>Method: </bold>Fifteen patients with acute severe bronchial asthma (ASBA) were prospectively studied in the intensive care unit (ICU) with continuous electrocardiograph (ECG). Plasma CK, CK-MB, myoglobin and cTT were measured at 0, 4, 8, 12, 16 and 20 h in the ICU.<bold>Results: </bold>Five out of 15 ASBA patients had elevated CK, four of them presenting with an increase in CK-MB. Plasma cTT was normal in every patient, including those with CK and/or myoglobin elevation. At admission to the ICU, myoglobin and CK were positively correlated (r = 0.760; p < 0.001). No patient was intubated. There was no difference in clinical signs or symptoms, medical history, laboratory values or ECG in patients with or without CK elevation.<bold>Conclusion: </bold>Patients admitted to an ICU for ASBA may present with an elevation of plasma CK, CK-MB and myoglobin not related to any heart injury. CK and CK-MB are not good markers of myocardial injury in ASBA patients due to the multitude of potential confounders. Therefore, troponin should be measured instead.
- Subjects
CREATINE kinase; MYOGLOBIN; ASTHMA; INTENSIVE care units; ELECTROCARDIOGRAPHY; SYMPTOMS
- Publication
Intensive Care Medicine, 2001, Vol 27, Issue 3, p528
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s001340100854