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- Title
Tuberculosis and the Risk of Ischemic Heart Disease: A Nationwide Cohort Study.
- Authors
Lee, Han Rim; Yoo, Jung Eun; Choi, Hayoung; Han, Kyungdo; Lim, Young-Hyo; Lee, Hyun; Shin, Dong Wook
- Abstract
Background Little is known about the risk of ischemic heart disease (IHD) in tuberculosis (TB) survivors. Methods We performed a population-based retrospective cohort study using the Korean National Health Insurance Service database. TB survivors (n = 60 602) and their 1:1 age- and sex-matched controls (n = 60 602) were enrolled. Eligible participants were followed up from 1 year after their TB diagnosis to the date of an IHD event, date of death, or the end of the study period (31 December 2018), whichever came first. The risk of IHD was estimated using a Cox proportional hazards regression, and stratified analyses were performed for related factors. Among IHD events, we additionally analyzed for myocardial infarction (MI). Results During a median of 3.9 years of follow-up, 2.7% of TB survivors (1633/60 602) and 2.0% of the matched controls (1228/60 602) developed IHD, and 0.6% of TB patients (341/60 602) and 0.4% of the matched controls (223/60 602) developed MI. The overall risk of developing IHD and MI was higher in TB patients (adjusted hazard ratio [aHR] 1.21, 95% confidence interval [CI]: 1.12–1.32 for IHD and aHR 1.48, 95% CI: 1.23–1.78 for MI) than in the matched controls. Stratified analyses showed that TB survivors have an increased risk of IHD and MI regardless of income, place of residence, smoking status, alcohol consumption, physical activity, body mass index, and Charlson comorbidity index. Conclusions TB survivors have a higher risk of IHD than matched controls. Strategies are needed to reduce the burden of IHD in TB survivors.
- Subjects
TUBERCULOSIS prognosis; TUBERCULOSIS diagnosis; HEART disease risk factors; CONFIDENCE intervals; MYOCARDIAL ischemia; AGE distribution; RETROSPECTIVE studies; REGRESSION analysis; MYOCARDIAL infarction; RISK assessment; NATIONAL health services; SEX distribution; INCOME; DESCRIPTIVE statistics; STATISTICAL sampling; ODDS ratio; LONGITUDINAL method; COMORBIDITY; PROPORTIONAL hazards models; DISEASE risk factors
- Publication
Clinical Infectious Diseases, 2023, Vol 76, Issue 9, p1576
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciac946