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- Title
Seroreactivity to Kaposi's sarcoma‐associated herpesvirus (human herpesvirus 8) latent nuclear antigen in AIDS‐associated Kaposi's sarcoma patients depends on CD4+ T‐cell count.
- Authors
Vanda Akico Ueda Fick de Souza; Ligia Camera Pierrotti; Laura Masami Sumita; Wilton Santos Freire; Aluisio Augusto Cotrim Segurado; Cláudio Sérgio Pannuti
- Abstract
In AIDS/Kaposi's sarcoma (KS) patients, the sensitivity of immunofluorescence assays for detecting antibodies against latent nuclear antigen ranges from 52% to 93%. However, in classic and African KS, sensitivities above 90% have been reported systematically. This study evaluates whether CD4+ T‐cell count affects seroreactivity to KSHV LANA and to lytic antigens in AIDS/KS patients. Kaposi's sarcoma‐associated herpesvirus (KSHV) latent (IFA‐LANA) and lytic (IFA‐Lytic and ORF65/K8.1 EIA) antibodies were screened in 184 consecutive samples taken from 36 AIDS/KS patients grouped according to their CD4+ counts as follows: 300 (group C) cells/mm3. At enrollment, the immunofluorescence assay for the detection of antibodies against latent nuclear antigen (IFA‐LANA) was positive in 3/11(27.2%) group A patients, in 10/11 (90.9%) group B patients, and in 14/14 (100%) group C patients (P 300 cells/mm3 as a positive gold standard is recommended. J. Med. Virol. 79:1562–1568, 2007. © Wiley‐Liss, Inc.
- Subjects
AIDS patients; TUMORS; IMMUNOGLOBULINS; FLUORESCENCE
- Publication
Journal of Medical Virology, 2007, Vol 79, Issue 10, p1562
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.20949