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- Title
Predictive Genetic Testing of a Bone Marrow Recipient-Ethical Issues Involving Unexpected Results, Gender Issues, Test Accuracy, and Implications for the Donor.
- Authors
Sexton, A.; Rawlings, L.; Jenkins, M.; Winship, I.
- Abstract
We present a case where an apparently straightforward Lynch syndrome predictive genetic test of DNA from a blood sample from a woman yielded an unexpected result of X/Y chromosome imbalance. Furthermore, it demonstrates the complexities of genetic testing in people who have had bone marrow transplants. This highlights the potential for multiple ethical and counselling challenges, including the inadvertent testing of the donor. Good communication between clinics and laboratories is essential to overcome such challenges and to minimise the provision of false results.
- Subjects
GENETIC testing &; ethics; LYNCH syndrome II; BONE marrow transplantation; GENETIC counseling; GENETIC mutation; SEX chromosome abnormalities; DIAGNOSIS
- Publication
Journal of Genetic Counseling, 2014, Vol 23, Issue 1, p33
- ISSN
1059-7700
- Publication type
Article
- DOI
10.1007/s10897-013-9643-x