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- Title
The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation
- Authors
E. Vamos, Edith; Boros, Imre M.
- Abstract
Abstract: ADA2 adaptor proteins are essential subunits of GCN5-containing histone acetyltransferase (HAT) complexes. In metazoa ADA2a is present in the histone H4-specific ATAC, and ADA2b in the histone H3-specific SAGA complex. Using domain-swapped ADA2 chimeras, we determined that the in vivo function of Drosophila melanogaster SAGA and ATAC HAT complexes depend on the C-terminal region of the ADA2 subunit they contain. Our findings demonstrate that the ADA2 C-terminal regions play an important role in the specific incorporation of ADA2 into SAGA- or ATAC-type complexes, which in turn determines H3- or H4-specific histone targeting.
- Subjects
C-terminal binding proteins; HISTONE acetylation; HISTONE acetyltransferase; DROSOPHILA melanogaster; METAZOA; GENE targeting
- Publication
FEBS Letters, 2012, Vol 586, Issue 19, p3279
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.06.051