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- Title
Peroxisome proliferator-activated receptor γ regulates angiotensin II-induced catalase downregulation in adventitial fibroblasts of rats
- Authors
Yang, Weiwei; Zhang, Jia; Wang, Haiya; Shen, Weili; Gao, Pingjin; Singh, Manpreet; Fang, Ningyuan
- Abstract
Abstract: Peroxisome proliferator-activated receptor (PPAR) γ ligands oppose the effect induced by angiotensin II (Ang II) to reduce oxidative stress and improve antioxidant status. In this study, Ang II inhibited catalase (CAT) and peroxisome proliferator-activated receptor γ (PPAR γ) protein and mRNA expressions. Transfection with PPAR γ small-interfering RNA (siRNA) led to a reduction in CAT expression. PPAR γ ligands enhanced CAT expression and inhibited extracellular signal-regulated kinase 1/2 activation. We further reveal that Ang II type 1 receptor is not involved in the inhibitory effects of PPAR γ ligands on Ang II stimulatory events.
- Subjects
PEROXISOMES; ANGIOTENSIN-receptor blockers; CATALASE; FIBROBLASTS; CELL proliferation; MESSENGER RNA; LABORATORY rats
- Publication
FEBS Letters, 2011, Vol 585, Issue 5, p761
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.01.040