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- Title
Neurosteroid enhances glutamate release in rat prelimbic cortex via activation of a<sub>1</sub>-adrenergic and s<sub>1</sub> receptors.
- Authors
Dong, Y.; Fu, Y.-M.; Sun, J.-L.; Zhu, Y.-H.; Sun, F.-Y.; Zheng, P.
- Abstract
The present paper studied the effect and mechanism of neurosteroid pregnenolone sulfate (PREGS) on spontaneous glutamate release using electrophysiological and biochemical methods combined with a pharmacological approach. The results suggested that PREGS had a selective enhancing effect on spontaneous glutamate release in the prelimbic cortex and the hippocampus but not in the striatum. The effect of PREGS in the prelimbic cortex appeared to be via modulation of a1-adrenergic and s1 receptors, but in the hippocampus it might be dependent on s1 receptors only. The activation of a1-adrenergic receptors synergized s1 receptor activation in the prelimbic cortex. Intracellular calcium released from the endoplasmic reticulum, protein kinase C, adenylyl cyclase and protein kinase A played a key role in the effect of PREGS. Intracellular calcium, protein kinase C and adenylyl cyclase might be upstream events in the activation of protein kinase A after PREGS.
- Subjects
ADRENERGIC receptors; DRUG receptors; SYMPATHETIC nervous system; GLUTAMATE decarboxylase; PROTEIN kinases
- Publication
Cellular & Molecular Life Sciences, 2005, Vol 62, Issue 9, p1003
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-005-5004-8