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- Title
Influence of Medical History in Parents or Siblings on the Development of Systemic Lupus Erythematosus among Japanese Females.
- Authors
Yoshifumi Tada; Masakazu Washio; Takahiko Horiuchi; Chikako Kiyohara; Hiroki Takahashi; Gen Kobashi; Yuichiro Ide; Tatsuya Atsumi; Toyoko Asami
- Abstract
Objective: To examine the influence of medical history in parents or siblings on the development of systemic lupus erythema-tosus (SLE) among Japanese females. Methods: 160 female SLE patients and 660 female volunteers were studied in a case-control study. Unconditional logistic regression was used to compute OR and 95% Cl, with adjustment for smoking, drinking, age and region. Results: The present study demonstrated that the risk of SLE was positively associated with family histories (i.e., medical histories in parents or siblings) of SLE (OR = 5.38, 95%CI = 1.43-20.20), rheumatoid arthritis (OR = 2.54, 95%CI = 1.08-5.96), collagen diseases (OR = 3.48, 95%CI = 1.87-6.48) and autoimmune diseases (OR = 5.25, 95%CI = 1.64-16.83). Conclusion: The result of the present study implies that common genetic and potential environmental factors among family members may lead to SLE, rheumatoid arthritis, and autoimmune diseases.
- Subjects
SIBLINGS; JAPANESE people; SYSTEMIC lupus erythematosus; LOGISTIC regression analysis; CASE-control method
- Publication
International Medical Journal, 2016, Vol 23, Issue 5, p466
- ISSN
1341-2051
- Publication type
Article