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- Title
Laminarly Orthogonal Excitation of Fast-Spiking and Low-Threshold-Spiking Interneurons in Mouse Motor Cortex.
- Authors
Apicella, Alfonso J.; Wickersham, Ian R.; Seung, H. Sebastian; Shepherd, Gordon M. G.
- Abstract
In motor cortex, long-range output to subcortical motor circuits depends on excitatory and inhibitory inputs converging on projection neurons in layers 5A/B. How interneurons interconnect with these projection neurons, and whether these microcircuits are interneuron and/or projection specific, is unclear. We found that fast-spiking interneurons received strong intralaminar (horizontal) excitation from pyramidal neurons in layers 5A/B including corticostriatal and corticospinal neurons, implicating them in mediating disynaptic recurrent, feedforward, and feedback inhibition within and across the two projection classes. Low-threshold-spiking (LTS) interneurons were instead strongly excited by descending interlaminar (vertical) input from layer 2/3 pyramidal neurons, implicating them in mediating disynaptic feedforward inhibition to both projection classes. Furthermore, in a novel pattern, lower layer 2/3 preferentially excited interneurons in one layer (5A/LTS) and excitatory neurons in another (5B/corticospinal). Thus, these inhibitory microcircuits in mouse motor cortex follow an orderly arrangement that is laminarly orthogonalized by interneuron-specific, projection-nonspecific connectivity.
- Subjects
INTERNEURONS; MOTOR cortex; LABORATORY mice; NEURAL circuitry; NEURONS; PYRAMIDAL tract
- Publication
Journal of Neuroscience, 2012, Vol 32, Issue 20, p7021
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0011-12.2012