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- Title
Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context.
- Authors
Nkuba-Ndaye, Antoine; Mukadi-Bamuleka, Daniel; Bulabula-Penge, Junior; Thaurignac, Guillaume; Edidi-Atani, François; Mambu-Mbika, Fabrice; Danga-Yema, Bernice; Matondo-Kuamfumu, Meris; Kinganda-Lusamaki, Eddy; Bisento, Nella; Lumembe-Numbi, Raphaël; Kabamba-Lungenyi, Gabriel; Kitsa-Mutsumbirwa, Divine; Kambale-Sivihwa, Nelson; Boillot, François; Delaporte, Eric; Mbala-Kingebeni, Placide; Ayouba, Ahidjo; Peeters, Martine; Ahuka-Mundeke, Steve
- Abstract
<bold>Background: </bold>Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence.<bold>Methods: </bold>Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1-4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo.<bold>Results: </bold>After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases.<bold>Conclusions: </bold>These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative.
- Publication
Journal of Infectious Diseases, 2022, Vol 226, Issue 2, p352
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiac057