We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Indolizine Derivatives as HIV-1 VIF-Elongin C Interaction Inhibitors.
- Authors
Huang, Wenlin; Zuo, Tao; Luo, Xiao; Jin, Hongwei; Liu, Zhenming; Yang, Zhenjun; Yu, Xianghui; Zhang, Liangren; Zhang, Lihe
- Abstract
Compound 1 ( VEC-5) was identified as a potent small-molecular HIV-1 viron infectivity factor inhibitor that targets the viron infectivity factor-Elongin C interaction. A structure-activity relationship study was carried out to develop compounds with improved efficacy against HIV-1 and 49 indolizine derivatives of three categories were designed and synthesized. We found that five compounds exhibited promising anti- HIV-1 activity, and the most active compound 2g had an IC50 value of 11.0 μ m. These results provide new information to develop highly potent small-molecule HIV-1 viron infectivity factor inhibitors.
- Subjects
HIV; ELONGINS; STRUCTURE-activity relationship in pharmacology; DRUG efficacy; BIOACTIVE compounds; VIRION
- Publication
Chemical Biology & Drug Design, 2013, Vol 81, Issue 6, p730
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/cbdd.12119