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- Title
The effect of low-dose ketamine on fentanyl-induced respiratory depression.
- Authors
Mildh, L; Taittonen, M; Leino, K; Kirvelä, O
- Abstract
This study evaluated if adding low-dose ketamine to fentanyl could offer a haemodynamically stable drug combination with little respiratory side-effects. Eight healthy, consenting male volunteers received in a random, cross-over and double-blind fashion both fentanyl 2 μgkg-1 + ketamine 0.25 mgkg-1 and fentanyl 2 μgkg-1 + placebo. The fentanyl and placebo reduced minute ventilation, alveolar ventilation and oxygen consumption ( p < 0.05), with little effect on haemodynamics. After fentanyl and ketamine, the decrease in minute ventilation and alveolar ventilation was attenuated compared to the placebo-containing combination ( p < 0.05), but with a simultaneous increase in oxygen consumption ( p < 0.05) and stimulation of haemodynamics ( p < 0.05). Both treatments decreased oxygen saturation and arterial oxygen pressure similarly. Ketamine thus attenuated the fentanyl-induced reduction in ventilation without preventing the decrease in blood oxygenation. In conclusion, combining low-dose ketamine to fentanyl offers no benefits in terms of preventing respiratory depression.
- Subjects
KETAMINE; FENTANYL; RESPIRATORY distress syndrome; PHYSIOLOGY
- Publication
Anaesthesia, 1998, Vol 53, Issue 10, p965
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1046/j.1365-2044.1998.00519.x