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- Title
Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients.
- Authors
Tarnow, Lise; Cambien, Francois; Rossing, Peter; Nielsen, Flemming S.; Hansen, Birgitte V.; Lecerf, Laure; Poirier, Odette; Danilov, Sergei; Parving, Hans-Henrik; Tarnow, L; Cambien, F; Rossing, P; Nielsen, F S; Hansen, B V; Lecerf, L; Poirier, O; Danilov, S; Parving, H H
- Abstract
Genotypic abnormalities of the renin-angiotensin system have been suggested as a risk factor for the development of diabetic nephropathy and proliferative retinopathy. We studied the relationship between an insertion(I)/deletion (D) polymorphism in the angiotensin-converting enzyme (ACE) gene in insulin-dependent diabetes mellitus (IDDM) patients with diabetic nephropathy (121 men and 77 women, age 40.9 +/- 10 years, diabetes duration 27 +/- 8 years) and in IDDM patients with normoalbuminuria (118 men and 74 women, age 42.7 +/- 10 years, diabetes duration 26 +/- 8 years). A total of 155 patients (40%) had proliferative retinopathy, and 67 patients (17%) had no diabetic retinopathy. There was no difference in genotype distribution between IDDM patients with diabetic nephropathy and those with normalbuminuria: 63 (32%)/95 (48%)/40 (20%) vs. 67 (35%)/77 (41%)/46 (24%) had DD/ID/II genotypes, respectively. Patients with nephropathy had higher plasma ACE levels (609 [151-1,504] micrograms/l) compared with patients with normoalbuminuria (428 [55-1,630] micrograms/l) (P < 0.001). Multiple linear regression analysis revealed that the plasma ACE level in patients with nephropathy is partially determined by ACE/ID polymorphism, mean arterial blood pressure, and glomerular filtration rate (r2 = 0.30, P < 0.001). There was no difference in genotype distribution between IDDM patients with proliferative retinopathy and those without diabetic retinopathy: 52 (34%)/74 (48%)/29 (19%) vs. 26 (39%)/25 (37%)/16 (24%) had DD/ID/II genotypes, respectively. There was also no difference in plasma ACE concentration detected among patients with no, simplex, or proliferative retinopathy.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects
ANGIOTENSIN converting enzyme; DIABETIC nephropathies; DIABETIC retinopathy; GENETIC polymorphisms; TYPE 1 diabetes; CROSS-sectional method; CASE-control method; GENOTYPES; DISEASE complications
- Publication
Diabetes, 1995, Vol 44, Issue 5, p489
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.44.5.489