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- Title
The ratio between the whole-body and primary tumor burden, measured on <sup>18</sup>F-FDG PET/CT studies, as a prognostic indicator in advanced non-small cell lung cancer.
- Authors
Alves Oliveira, Felipe Renê; de Oliveira Santos, Allan; Lopes de Lima, Mariana da Cunha; Contrera Toro, Ivan Felizardo; Ferreira de Souza, Thiago; Juarez Amorim, Bárbara; Souza Barbeiro, Aristoteles; Etchebehere, Elba
- Abstract
Objective: To determine whether the whole-body tumor burden, as quantified by 18F-fluorodeoxyglucose positron-emission tomography/ computed tomography (18F-FDG PET/CT), is a prognostic indicator in advanced (stage III or IV) non-small cell lung cancer (NSCLC). Materials and Methods: This was a prospective study in which we evaluated 18F-FDG PET/CT staging parameters to quantify tumor burdens in patients with stage III or IV NSCLC. The following parameters were evaluated for the whole body (including the primary tumor) and for the primary tumor alone, respectively: maximum standardized uptake volume (wbSUVmax and tuSUVmax); metabolic tumor volume (wbMTV and tuMTV); and total lesion glycolysis (wbTLG and tuTLG). To determine whether the 18F-FDG PET/CT parameters were associated with overall survival (OS) and progression-free survival (PFS), we evaluated the wbSUVmax/tuSUVmax, wbMTV/tuMTV, and wbTLG/tuTLG ratios. Results: 18F-FDG PET/CT was performed for staging in 52 patients who were followed for a median of 11.0 months (mean, 11.7 months). The estimated median PFS and OS were 9.6 months and 11.6 months, respectively. In the univariate analysis, OS was found to correlate significantly with wbTLG (hazard ratio [HR] = 1.001; 95% confidence interval [95 CI]: 1.000-1.001; p = 0.0361) and with the wbTLG/tuTLG ratio (HR = 1.705; 95% CI: 1.232-2.362; p = 0.0013). In the multivariate analysis, only the wbTLG/tuTLG ratio was independently associated with OS (HR = 1.660; 95% CI: 1.193-2.310; p = 0.0027). Conclusion: The wbTLG/tuTLG ratio is an independent prognostic indicator of OS in advanced-stage NSCLC.
- Subjects
NON-small-cell lung carcinoma; POSITRON emission tomography computed tomography; PROGRESSION-free survival; OVERALL survival
- Publication
Radiologia Brasileira, 2021, Vol 54, Issue 5, p289
- ISSN
0100-3984
- Publication type
Article
- DOI
10.1590/0100-3984.2020.0054