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- Title
A cross-eyed geneticist’s view.
- Authors
Kasbekar, Durgadas P
- Abstract
The vertebrate inner nuclear membrane protein, lamin B receptor, has an N-terminal ~200 residue nucleoplasmic domain (NTD), and a ~420 residue C-terminal domain (CTD) that anchors the NTD to the INM. Chen <italic>et al</italic> (<xref>2016</xref>) showed the NTD interacts with Xist long noncoding RNA to effect X chromosome inactivation in female mammals. Tsai <italic>et al</italic> (<xref>2016</xref>) showed the CTD has sterol reductase activity that is essential for viability. And Nikolakaki <italic>et al</italic> (<xref>2017</xref>) proposed a model to interconnect these disparate functions of this chimeric protein. It amuses me now to think back to 24 years ago, when I was concerned that these domains might have come together in a cloning artifact.
- Subjects
GENE expression; MOLECULAR genetics; GENETIC mutation; X chromosome; DROSOPHILA; CHROMATIN-remodeling complexes; PROTEIN expression
- Publication
Journal of Biosciences, 2018, Vol 43, Issue 2, p235
- ISSN
0250-5991
- Publication type
Article
- DOI
10.1007/s12038-018-9757-2