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- Title
Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial.
- Authors
Xue, Jing-xian; Ye, Bei; Liu, Shun; Cao, Si-han; Bian, Wei-he; Yao, Chang
- Abstract
Objective. To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response. Methods. Herein, 40 patients with IGM who had wounds requiring dressing change were enrolled and randomly divided into two groups: the CLY group and the control group. The size of the neoplasm and pain score of patients were followed-up for 4 weeks. Local tissues were taken during dressing change and examined by commercial enzyme-linked immunosorbent assay (ELISA) kits. The levels of inflammatory markers, including interleukin-1β (IL-1β), IL-2, IL-6, interferon gamma (IFN-γ), and tumor necrosis factor-α (TNF-α) were measured. Results. After treatment, the size of the neoplasm in the CLY group was significantly smaller than that in the control group (14.28 cm ± 8.96 cm vs. 21.14 cm ± 0.12 cm, P = 0.038), and the pain scores were markedly reduced (P = 0.004). Besides, CLY downregulated the expression levels of IL-1β, IFN-γ, and TNF-α. Conclusion. External use of CLY could reduce the neoplasm of IGM by inhibiting local inflammation. This trial is registered with ChiCTR1800017744.
- Subjects
TUMOR diagnosis; CLOTHING &; dress; ENZYME-linked immunosorbent assay; GENE expression; HERBAL medicine; INTERFERONS; INTERLEUKINS; MASTITIS; CHINESE medicine; MOLECULAR structure; TUMOR necrosis factors; TUMORS; PAIN measurement; RANDOMIZED controlled trials; TREATMENT effectiveness; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2020, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2020/6964801