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- Title
Comparison of first-line immunotherapy efficacy between advanced lung squamous cell carcinoma and pulmonary lymphoepithelioma-like carcinoma: A propensity score matching multicenter study.
- Authors
YuBin Zhou; Jian Huang; Jun Lan; Hao Hu; Zihao Yuan; Longyan Dong; Huiyin Deng; Li-ao Yue; Yi Xiao; Xiongwen Yang
- Abstract
Background: Compared with other lung squamous cell carcinomas (LUSC), pulmonary lymphoepithelioma-like carcinoma (pLELC) is closely associated with Epstein--Barr virus (EBV) infections with a unique molecular profile and immune microenvironment. This study was thus established to compare the treatment response and effectiveness of immunotherapy between pLELC and LUSC. Material and Methods: We enrolled 31 patients with pLELC and 116 with LUSC receiving first-line immunotherapy at three centers in China and compared the treatment response and effectiveness of immunotherapy. Propensity score matching (PSM) was used to balance the differences in baseline data between the two groups. Results: Before PSM, progression-free survival and overall survival were longer in the pLELC group than in the LUSC group (progression-free survival: hazard ratio (HR), 1.67, 95% CI: 1.05-2.63, P = 0.028; overall survival: HR, 1.90, 95% CI: 1.06-3.40, P = 0.028). This remained unchanged after PSM (progression-free survival: HR, 1.79, 95% CI: 1.02-3.15, P = 0.044; overall survival: HR, 2.20; 95% CI: 1.10-4.37, P = 0.022). Conclusion: pLELC showed a clinically meaningful survival benefit compared with traditional LUSC following immunotherapy. Subsequent studies should consider the role of the EBV in the tumor immune microenvironment of pLELC.
- Subjects
CHINA; SQUAMOUS cell carcinoma; PROPENSITY score matching; IMMUNOTHERAPY; PROGRESSION-free survival; CARCINOMA
- Publication
Journal of Cancer Research & Therapeutics, 2023, Vol 19, Issue 4, p1011
- ISSN
0973-1482
- Publication type
Article
- DOI
10.4103/jcrt.jcrt_2711_22