We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Genotype-phenotype correlations with personality traits of healthcare professionals: a new use for the Human Genome Project.
- Authors
Fitzgerald, Dominic A; Isaacs, David
- Abstract
<bold>Objective: </bold>To describe the genetic basis of various personality traits.<bold>Design: </bold>Prospective, blinded cohort study comparing questionnaire-reported personality traits with candidate genes for temperament, as revealed by genetic mapping in the Human Genome Project. Non-supervised questionnaires were mailed to MJA subscribers. DNA extracted from newborn screening blood samples of all New South Wales participants was used to perform mutation analysis for candidate personality genes.<bold>Setting: </bold>Tertiary medical care in New South Wales, 1 April 2000 to 1 April 2001.<bold>Participants: </bold>Healthcare professionals who admitted to reading the MJA on at least a semi-regular (monthly) basis.<bold>Main Outcome Measures: </bold>Correlations between occupation, personality and gene mutations were sought using a LOD score in comparison with a classic Poisson d'avril distribution.<bold>Results: </bold>Mutations were identified that suggested the existence of genes determining several personality traits. Genes coding for belligerence (bel), charisma (lub), cynicism (dub), housekeeping (vac and uum), lack of personality (dul-1), obsessive-compulsive behaviour (pic-e) and gullibility (suk-r) are described. These were found to be selectively represented in certain members of the healthcare profession.<bold>Conclusions: </bold>The seven most important healthcare personality genes have now been described for posterity.
- Publication
Medical Journal of Australia, 2002, Vol 176, Issue 7, p339
- ISSN
0025-729X
- Publication type
journal article
- DOI
10.5694/j.1326-5377.2002.tb04436.x