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- Title
Copper-Catalyzed Mild Nitration of Protected Anilines.
- Authors
Hernando, Elier; Castillo, Rafael R.; Rodríguez, Nuria; Gómez Arrayás, Ramón; Carretero, Juan C.
- Abstract
A practical copper-catalyzed direct nitration of protected anilines, by using one equivalent of nitric acid as the nitrating agent, has been developed. This procedure features mild reaction conditions, wide structural scope (with regard to both N-protecting group and arene substitution), and high functional-group tolerance. Dinitration with two equivalents of nitric acid is also feasible.
- Subjects
NITRATION; ANILINE; COPPER catalysts; NITRIC acid; AROMATIC compounds
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 43, p13854
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201404000