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- Title
Effects of gadolinium-based MRI contrast agents on liver tissue.
- Authors
Mercantepe, Tolga; Tümkaya, Levent; Çeliker, Fatma Beyazal; Topal Suzan, Zehra; Çinar, Seda; Akyildiz, Kerimali; Mercantepe, Filiz; Yilmaz, Adnan
- Abstract
<bold>Background: </bold>MRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium-based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models.<bold>Purpose: </bold>To compare the effects on liver tissue of gadolinium-based MRI contrast agents in the light of biochemical and histopathological evaluation.<bold>Study Type: </bold>Institutional Review Board (IRB)-approved controlled longitudinal study.<bold>Animal Model: </bold>In all, 32 male Sprague-Dawley rats were divided into a healthy control group subjected to no procedure (Group 1), a sham group (Group 2), a gadodiamide group (Group 3), and a gadoteric acid group (Group 4).<bold>Field Strength/sequence: </bold>Not applicable.<bold>Assessment: </bold>Liver tissues removed at the end of the fifth week and evaluated pathologically (scored Knodell's histological activity index [HAI] method by two histopathologists) immunohistochemical (caspase-3 and biochemical tests (AST, ALT, TAS, TOS, and OSI method by Erel et al) were obtained.<bold>Statistical Tests: </bold>Differences between groups were analyzed using the nonparametric Kruskal-Wallis test followed by the Tamhane test, and one-way analysis of variance (ANOVA) followed by Turkey's HSD test.<bold>Results: </bold>An increase was observed in histological activity scores in sections from rats administered gadodiamide and gadoteric acid, and in caspase-3, AST and ALT values (P < 0.05). In contrast, we determined no change in TOS (P = 0.568 and P = 0.094, respectively), TAS (P = 0.151 and P = 0.055, respectively), or OSI (P = 0.949 and P = 0.494, respectively) values.<bold>Data Conclusion: </bold>These data suggest that gadodiamide and gadoteric acid trigger hepatocellular necrosis and apoptosis by causing damage in hepatocytes, although no change occurs in total antioxidant and antioxidant capacity.<bold>Level Of Evidence: </bold>1 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2018;47:1367-1374.
- Publication
Journal of Magnetic Resonance Imaging, 2018, Vol 47, Issue 4, pN.PAG
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.26031