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- Title
Diffusion kurtosis MRI versus conventional diffusion-weighted imaging for evaluating inflammatory activity in Crohn's disease.
- Authors
Huang, Li; Li, Xue‐hua; Huang, Si‐yun; Zhang, Zhong‐wei; Yang, Xu‐feng; Lin, Jin‐jiang; Jiang, Meng‐jie; Feng, Shi‐ting; Sun, Can‐hui; Li, Zi‐ping; Li, Xue-Hua; Huang, Si-Yun; Zhang, Zhong-Wei; Yang, Xu-Feng; Lin, Jin-Jiang; Jiang, Meng-Jie; Feng, Shi-Ting; Sun, Can-Hui; Li, Zi-Ping
- Abstract
<bold>Purpose: </bold>To assess the efficacy of diffusion kurtosis imaging (DKI) and to compare DKI-derived parameters with that of conventional diffusion-weighted imaging (DWI) for grading the inflammatory activity of Crohn's disease (CD).<bold>Materials and Methods: </bold>In all, 38 patients with CD underwent 3T magnetic resonance enterography (MRE) with DKI (b values of 0-2000 s/mm2 ). The inflammatory activity of the bowel segments was graded by magnetic resonance index of activity (MaRIA) as inactive (<7), mild (≥7 and <11), or moderate-severe (≥11). Apparent diffusion for non-Gaussian distribution (Dapp ) and apparent kurtosis coefficient (Kapp ) on DKI as well as apparent diffusion coefficient (ADC) on DWI were compared.<bold>Results: </bold>In all, 86 bowel segments including inactive (20), mild (19), and moderate-severe (47) CD were analyzed. The differences in Kapp , Dapp , and ADC among inactive, mild, and moderate-severe CD were significant (all P < 0.05). Kapp (r = 0.862), Dapp (r = -0.755), and ADC (r = -0.713) correlated well with MaRIA in all segments. Stronger correlation with MaRIA in moderate-severe CD was found for Kapp (r = 0.647) than that of Dapp (r = -0.414) and ADC (r = -0.580). Receiver operating characteristic (ROC) curve analysis showed high accuracy of Kapp , Dapp , and ADC for differentiating active from inactive CD (AUC: 0.953 for Kapp , 0.944 for Dapp , 0.907 for ADC) as well as differentiating inactive-mild from moderate-severe CD (AUC: 0.946 for Kapp , 0.887 for Dapp , 0.846 for ADC). The threshold Kapp of 0.731 allowed differentiation of active from inactive CD with 89.4% sensitivity and 95% specificity.<bold>Conclusion: </bold>DKI of CD is clinically feasible and might be superior to conventional DWI for grading the inflammatory activity of CD.<bold>Level Of Evidence: </bold>2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:702-709.
- Publication
Journal of Magnetic Resonance Imaging, 2018, Vol 47, Issue 3, p702
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25768