We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Lung adenocarcinoma: Assessment of epidermal growth factor receptor mutation status based on extended models of diffusion-weighted image.
- Authors
Yuan, Mei; Pu, Xue‐Hui; Xu, Xiao‐Quan; Zhang, Yu‐Dong; Zhong, Yan; Li, Hai; Wu, Jiang‐Fen; Yu, Tong‐Fu; Pu, Xue-Hui; Xu, Xiao-Quan; Zhang, Yu-Dong; Wu, Jiang-Fen; Yu, Tong-Fu
- Abstract
<bold>Purpose: </bold>To evaluate the diagnostic performance of extended models of diffusion-weighted (DW) imaging to help differentiate the epidermal growth factor receptor (EGFR) mutation status in stage IIIA-IV lung adenocarcinoma.<bold>Materials and Methods: </bold>This retrospective study had institutional research board approval and was HIPAA compliant. Preoperative extended DW imaging including intravoxel incoherent motion (IVIM) and diffusional kurtosis imaging (DKI) 3 Tesla MRI were retrospectively evaluated in 53 patients with pathologically confirmed non-early stage (IIIA-IV) lung adenocarcinoma. EGFR mutationsat exons 18-21 were determined by using polymerase chain reaction-based ARMS. Quantitative parameters (mean, kurtosis, skewness, 10th and 90th percentiles) of IVIM (true-diffusion coefficient D, pseudo-diffusion coefficient D*, and perfusion fraction f) and DKI (kurtosis value Kapp, kurtosis corrected diffusion coefficient Dapp) were calculated by outlining entire-volume histogram analysis. Receiver operating characteristic analysis was constructed to determine the diagnostic performance of each parameter. Multivariate logistic regression was used to differentiate the probability of EGFR mutation status.<bold>Results: </bold>Twenty-four of 53 patients with lung adenocarcinoma were EGFR mutations, which occurred most often in acinar (10 of 13 [76.9%]) and papillary predominant tumors (9 of 13 [69.2%]). Patients with EGFR mutation showed significant higher 10th percentile of D, lower D* value in terms of kurtosis, and lower Kapp value in terms of mean, skewness, 10th and 90th percentiles (all P values < 0.05). The 90th Kapp showed significantly higher sensitivity (97%; P < 0.05) and Az (0.817; P < 0.05) value. Multivariate logistic regression showed 90th Kapp was a independent factor for determining EGFR mutation with odds ratio -1.657.<bold>Conclusion: </bold>Multiple IVIM and DKI parameters, especially the histogram 90th Kapp value, helped differentiate EGFR mutation status in stage IIIA-IV lung adenocarcinoma.<bold>Level Of Evidence: </bold>3 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:281-289.
- Subjects
ADENOCARCINOMA; BIOLOGICAL models; DIAGNOSTIC imaging; DISEASE susceptibility; EPIDERMAL growth factor; GENETIC polymorphisms; LUNG tumors; MAGNETIC resonance imaging; COMPUTERS in medicine; GENETIC mutation; RESEARCH evaluation; STATISTICAL models
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 46, Issue 1, p281
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25572