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- Title
MR Angiography of Carotid Artery Aneurysms in a Porcine Model at 3 Tesla: Comparison of Two Different Macrocyclic Gadolinium Chelates and of Dynamic and Conventional Techniques.
- Authors
Wuesten, Oliver; Morelli, John N.; Miller, Matthew W.; Tuzun, Egemen; Lenox, Mark W.; Fossum, Theresa W.; Trelles, Miguel; Cotes, Claudia; Krombach, Gabriele A.; Runge, Val M.
- Abstract
Purpose: To evaluate the differences in image quality of two macrocyclic gadolinium-based contrast agents, gadobutrol and gadoterate meglumine, using time-resolved, contrast-enhanced MR angiography (CE-MRA) in a porcine carotid artery aneurysm model and to compare image quality between dynamic and conventional, single acquisition CE-MRA. Materials and Methods: Bilateral carotid aneurysms were created surgically in this Institutional Animal Care and Use Committee approved study. Dynamic CE-MRA studies optimized for high temporal resolution were performed at 3 Tesla. Scans using equivalently dosed (on a per mmol basis) gadobutrol and gadoterate meglumine were compared qualitatively and quantitatively in terms of contrast-to-noise ratio (CNR). Higher spatial resolution dynamic and conventional CE-MRA were also compared. Results: N = 16 aneurysms were assessed. Qualitative evaluation of dynamic CE-MRA scans demonstrated a preference for gadobutrol over gadoterate meglumine. Significantly higher aneurysm CNR was found with gadobutrol (133 ± 44) versus gadoterate meglumine, the latter at both equivalent and double injection rates (94 ± 35 and 102 ± 38). In a blinded assessment, conventional CEMRA was preferred qualitatively when compared with dynamic CE-MRA. However, dynamic CE-MRA was generally capable of providing diagnostic image quality. Conclusion: Gadobutrol is preferred to gadoterate meglumine for high temporal resolution dynamic CE-MRA, a fact with important clinical implications for low dose CE-MRA protocols in patients at risk for nephrogenic systemic fibrosis. Conventional high resolution CE-MRA provides superior image quality when compared with dynamic CE-MRA.
- Publication
Journal of Magnetic Resonance Imaging, 2012, Vol 36, Issue 5, p1203
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.23757