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- Title
A prospective randomized comparative study to determine appropriate edoxaban administration period, to prevent deep vein thromboembolism in patients with total knee arthroplasty.
- Authors
Ishida, Kazunari; Shibanuma, Nao; Kodato, Kazuki; Toda, Akihiko; Sasaki, Hiroshi; Takayama, Koji; Hayashi, Shinya; Hashimoto, Shingo; Matsushita, Takehiko; Niikura, Takahiro; Kurosaka, Masahiro; Kuroda, Ryosuke; Matsumoto, Tomoyuki
- Abstract
<bold>Background: </bold>This study aimed to determine the appropriate administration duration of edoxaban 15 mg (a factor Xa inhibitor) for the prevention of deep vein thrombosis (DVT) after total knee arthroplasty (TKA).<bold>Methods: </bold>Our study comprised 202 patients who underwent TKA (excluding bilateral TKA) at our institution between 2014 and 2015. The subjects received edoxaban 15 mg daily for 1 (n = 93) or 2 (n = 109) weeks; group assignment was random. B-mode ultrasonography was performed 7 and 14 days post-TKA for the detection of DVT. We compared the incidence of DVT between the groups and examined for side effects.<bold>Results: </bold>The demographic data of the patients in the 1- and 2-week administration groups were similar at baseline. DVT incidence did not differ significantly between the groups at 1 week post-TKA. However, it was significantly lower in the 2-week administration group (n = 0) than in the 1-week administration group (n = 7; p = 0.004) at 2 weeks post-DVT. Neither group exhibited symptomatic DVT. A total of six patients withdrew during the study period because of hepatic dysfunction.<bold>Conclusions: </bold>Our results show that the administration of edoxaban 15 mg is more effective in preventing DVT after TKA when administered for 2 weeks than for 1 week.
- Subjects
THROMBOEMBOLISM; TOTAL knee replacement; VENOUS thrombosis; ULTRASONIC imaging; PROTHROMBIN; ARTHRITIS diagnosis; PREVENTION of surgical complications; THROMBOEMBOLISM prevention; VENOUS thrombosis prevention; ANTICOAGULANTS; ARTHRITIS; COMPARATIVE studies; DRUG administration; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PYRIDINE; RESEARCH; SURGICAL complications; THIAZOLES; VEINS; EVALUATION research; RANDOMIZED controlled trials; DISEASE incidence
- Publication
Journal of Orthopaedic Science, 2018, Vol 23, Issue 6, p1005
- ISSN
0949-2658
- Publication type
journal article
- DOI
10.1016/j.jos.2018.06.004