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- Title
Prenylated Flavonoid Glycosides with PCSK9 mRNA Expression Inhibitory Activity from the Aerial Parts of Epimedium koreanum.
- Authors
Kim, Eeray; Kim, Young-Mi; Ahn, Jongmin; Chae, Hee-Sung; Chin, Young-Won; Kim, Jinwoong
- Abstract
Phytochemical investigation on the n-BuOH-soluble fraction of the aerial parts of Epimedium koreanum using the PCSK9 mRNA monitoring assay led to the identification of four previously undescribed acylated flavonoid glycosides and 18 known compounds. The structures of new compounds were elucidated by NMR, MS, and other chemical methods. All isolated compounds were tested for their inhibitory activity against PCSK9 mRNA expression in HepG2 cells. Of the isolates, compounds 6, 7, 10, 15, and 17–22 were found to significantly inhibit PCSK9 mRNA expression. In particular, compound 7 was shown to increase LDLR mRNA expression. Thus, compound 7 may potentially increase LDL uptake and lower cholesterol levels in the blood.
- Subjects
EPIMEDIUM; MESSENGER RNA; FLAVONOID glycosides; BLOOD cholesterol; GLYCOSIDES; LOW density lipoproteins
- Publication
Molecules, 2021, Vol 26, Issue 12, p3590
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26123590