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- Title
Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras.
- Authors
Kouamé, Tapé; Okpekon, Aboua Timothée; Bony, Nicaise F.; N'Tamon, Amon Diane; Gallard, Jean-François; Rharrabti, Somia; Leblanc, Karine; Mouray, Elisabeth; Grellier, Philippe; Champy, Pierre; Beniddir, Mehdi A.; Le Pogam, Pierre
- Abstract
Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.
- Subjects
INDOLE alkaloids; FLAVONOIDS; BARK; MOLECULES
- Publication
Molecules, 2020, Vol 25, Issue 11, p2654
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25112654