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- Title
Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer's Disease.
- Authors
Zhang, Caiyun; Zhao, Xingming; Lin, Shiqi; Liu, Fangyuan; Ma, Jiahui; Han, Zhuo; Jia, Fujuan; Xie, Weidong; Zhang, Qian; Li, Xia
- Abstract
ent-Kaur-15-en-17-al-18-oic acid, extracted from the Chinese well known folk herb Leontopodium longifolium, performed a significantly neuroprotective effect on amyloid beta peptide 25-35 (Aβ25-35)-induced SH-SY5Y cells neurotoxicity in Alzheimer's disease. The results demonstrated that this compound maintained oxidative stress balance, reduced levels of reactive oxygen species (ROS), malondialdehyde (MDA), and improved contents of glutathione (GSH) and superoxide dismutase (SOD) without obvious cytotoxicity. This compound also obviously relieved oxidative stress-induced apoptosis associated with p53 and nuclear factor κB (NF-κB) pathways accompanied by upregulating B-cell lymphoma-2 (bcl-2) and downregulating p53, nuclear factor κB (NF-κB), Bax, Cleaved-caspase 3, and Cytochrome C protein expressions further. Briefly, ent-kaur-15-en-17-al-18-oic acid protected cells from oxidative apoptosis associated with p53 and NF-κB pathways.
- Subjects
ALZHEIMER'S disease; AMYLOID beta-protein; AMYLOID; APOPTOSIS; PROTEIN C; NEUROTOXICOLOGY
- Publication
Molecules, 2020, Vol 25, Issue 1, p142
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25010142